Flucytosine Antagonism of Azole Activity versus Candida glabrata: Role of Transcription Factor Pdr1 and Multidrug Transporter Cdr1
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چکیده
منابع مشابه
Flucytosine antagonism of azole activity versus Candida glabrata : 3 Role of transcription
9 10 Department of Microbiology and Immunology, Drexel University College of Medicine, 11 Philadelphia, Pennsylvania, 1 and Femeris Women’s Health Research Center, Medical Diagnostic 12 Laboratories, Hamilton, New Jersey 2 13 14 15 Running title: FLUCYTOSINE-AZOLE ANTAGONISM IN CANDIDA GLABRATA 16 17 18 * Corresponding author. Mailing address: Department of Microbiology and Immunology, Drexel 1...
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Candida glabrata has emerged as a common cause of fungal infection. This yeast has intrinsically low susceptibility to azole antifungals such as fluconazole, and mutation to frank azole resistance during treatment has been documented. Potential resistance mechanisms include changes in expression or sequence of ERG11 encoding the azole target. Alternatively, resistance could result from upregula...
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Case report-Subjects-Three cases are described oflong-standing vaginal candidosis due to Candida glabrata. These had failed to respond to local and systemic antifungals. In each case the infecting strain appeared resistant to a range of azole drugs in vitro. Clinical course-Case one-This patient recovered following prolonged treatment with oral itraconazole in combination with oral and vaginal ...
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The high prevalence of fluconazole resistance among clinical isolates of Candida glabrata has greatly hampered the utility of fluconazole for the treatment of invasive candidiasis. Fluconazole resistance in this yeast is almost exclusively due to activating mutations in the transcription factor Pdr1, which result in upregulation of the ABC transporter genes CDR1, PDH1, and SNQ2 and therefore in...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2013
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.02394-12